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Screening for vaginal shedding of cytomegalovirus in healthy pregnant women using real‐time PCR: Correlation of CMV in the vagina and adverse outcome of pregnancy
Author(s) -
Tanaka Kaori,
Yamada Hideto,
Minami Mashiho,
Kataoka Soromon,
Numazaki Kei,
Minakami Hisanori,
Tsutsumi Hiroyuki
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20619
Subject(s) - pregnancy , vagina , cytomegalovirus , miscarriage , medicine , obstetrics , viral shedding , human cytomegalovirus , genital tract , adverse effect , sex organ , gynecology , virology , herpesviridae , viral disease , virus , biology , physiology , surgery , genetics
The impact of cytomegalovirus (CMV) infection of the genital tract during pregnancy on adverse pregnancy outcomes is not understood fully. A real‐time PCR assay was used to determine vaginal shedding of CMV in 993 healthy pregnant Japanese women and the results were compared with the outcome of pregnancy. CMV DNA was detected in 76 (7.7%) of the women. The outcome of pregnancy could be determined finally in 848 women, of whom 60 (7.1%) were CMV positive. The carriers of CMV had an increased miscarriage rate (RR 6.96, 95% CI 2.04–23.84, P < 0.01). These findings suggest that latent genital tract CMV infection predisposes to adverse pregnancy outcomes. J. Med. Virol. 78:757–759, 2006. © 2006 Wiley‐Liss, Inc.