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Two cases of varicella zoster virus meningitis found in pediatric patients after bone marrow transplantation despite valaciclovir prophylaxis and without skin lesions
Author(s) -
Lévêque Nicolas,
Galambrun Claire,
Najioullah Fatiha,
Bleyzac Nathalie,
Pages MariePierre,
Bertrand Yves
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20570
Subject(s) - valaciclovir , medicine , varicella zoster virus , aciclovir , meningitis , virus , herpesviridae , transplantation , virology , viral disease , surgery
Two cases of varicella zoster virus (VZV) meningitis are described in an 18‐year‐old girl and an 18‐year‐old boy. They occurred, respectively, 9 days and 9 months after allogeneic bone marrow transplantation. VZV nucleic acid was detected in the cerebrospinal fluid during the 1st week of illness. This recurrence occured despite valaciclovir prophylaxis and without skin lesions. The two patients received aciclovir intravenously and immunoglobulins infusion. They responded to treatment and their clinical state improved rapidly. J. Med. Virol. 78:514–516, 2006. © 2006 Wiley‐Liss, Inc.