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Significance of hepatitis B virus genotypes A to E in a cohort of patients with chronic hepatitis B in the Seine Saint Denis District of Paris (France)
Author(s) -
GanneCarrié Nathalie,
Williams Virginie,
Kaddouri Halima,
Trinchet JeanClaude,
DziriMendil Samira,
Alloui Chakib,
Hawajri Nasser Al,
Dény Paul,
Beaugrand Michel,
Gordien Emmanuel
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20545
Subject(s) - hepatitis b virus , genotype , virology , medicine , hepatitis b , hepatocellular carcinoma , liver disease , virus , immunology , gastroenterology , biology , gene , biochemistry
The aim of this study was to examine the genetic variability of the hepatitis B virus (HBV) and its significance. HBV genotypes, core promoter and precore mutants were characterized in 109 consecutive patients with biopsy‐proven HBV chronic hepatitis. Genotypes A (26.6%), B (12.8%), C (18.3%), D (18.3%), and E (14.7%) indicate a wide genotypic distribution. Patients were from Asia (30.3%), Europe (28.4%), Sub Saharan Africa (23.9%), the Caribbean (10.1%), North Africa (5.5%), and Madagascar (1.8%). HBV genotypes A and D (HBV/A and /D) infected all subgroups except Asian patients. HBV/B or /C were found in 97% of Asian patients, whereas HBV/E only infected sub‐Saharan African and Caribbean patients. Differences according to genotypes were: an increased prevalence of anti‐HBe antibodies in patients infected with HBV/D ( P = 0.003), higher serum transaminases in patients infected with HBV/A and/D ( P = 0.043), more severe liver fibrosis in patients infected with HBV/A, /C and/D ( P = 0.02). Precore and core promoter mutants were found in 87% of anti‐HBe positive patients, and were associated with HBV/D ( P = 0.04) and severe liver fibrosis ( P = 0.002). It is concluded that HBV genotypes A, B, C, D, and E circulate in the Seine Saint Denis District, reflecting the geographical origin of patients. HBV/A, /C and/D seem to be associated with more severe hepatic disease. J. Med. Virol. 78:335–340, 2006. © 2006 Wiley‐Liss, Inc.