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Aberrant cellular immune responses in humans infected persistently with parvovirus B19
Author(s) -
Isa Adiba,
Norbeck Oscar,
Hirbod Taha,
Lundqvist Anders,
Kasprowicz Victoria,
Bowness Paul,
Klenerman Paul,
Broliden Kristina,
Tolfvenstam Thomas
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20514
Subject(s) - parvovirus , immune system , biology , virology , immunology , antigen , cellular immunity , immunity , genome , parvoviridae , virus , genetics , gene
A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19‐specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex‐vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2–8 years) showed larger number of responses to the structural proteins ( P = 0.0022), whereas responses to the non‐structural protein were of lower magnitude ( P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion. J. Med. Virol. 78:129–133, 2006. © 2005 Wiley‐Liss, inc.