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Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection
Author(s) -
Corcoran A.,
Crowley B.,
Dewhurst C.,
Pizer B.L.,
Doyle S.
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20513
Subject(s) - capsid , virology , parvoviridae , parvovirus , biology , resolution (logic) , virus , computer science , artificial intelligence
Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen‐specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non‐structural protein 1 (NS1). Determination of antigen‐specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection. J. Med. Virol. 78:125–128, 2006. © 2005 Wiley‐Liss, inc.