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Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
Author(s) -
Zhang Linqi,
Zhang Fengwen,
Yu Wenjie,
He Tian,
Yu Jian,
Yi Christopher E.,
Ba Lei,
Li Wenhui,
Farzan Michael,
Chen Zhiwei,
Yuen KwokYung,
Ho David
Publication year - 2006
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20499
Subject(s) - virology , antibody , coronavirus , glycoprotein , neutralizing antibody , disease , covid-19 , immunology , biology , medicine , antibody response , infectious disease (medical specialty) , microbiology and biotechnology
Most of the SARS‐CoV‐infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein‐specific and S glycoprotein‐specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS‐CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein‐specific and S glycoprotein‐specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS‐CoV‐infected patients. J. Med. Virol. 78:1–8, 2006. © 2005 Wiley‐Liss, inc.
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