Premium
Prevalence and partial sequence analysis of human T cell lymphotropic virus type I in China
Author(s) -
Wang Youchun,
Li Xiouhua,
Song Aijing,
Zhang Chuntao,
Chen Ying,
Chen Changrong,
Lin Yisheng,
Shun Liping,
Li Luilan,
Liu Yanchun,
Yang Jian,
Yang Bowei,
Tang Qiouping,
Harrison Tim J.
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20405
Subject(s) - virology , biology , virus , genotype , sequence analysis , antibody , southern china , china , volunteer , gene , genetics , geography , archaeology , agronomy
A total of 145,293 serum samples were collected from volunteer blood donors in 13 provinces of China and tested for anti‐HTLV antibody using an ELISA licensed in China. Thirty were positive for anti‐HTLV by ELISA and 19 of those 30 samples were confirmed positive using a supplemental immunoblot assay. Anti‐HTLV‐I was detected only in samples from Fujian province (a Southern province) where the positivity rate was approximately 0.05%. The region encoding gp46 from 5 of the 19 antibody positive samples was amplified and sequenced. Sequence analysis indicated that these isolates belong to HTLV‐I genotype A. These data suggest that HTLV‐I is not endemic throughout China and the virus may be restricted to a particular region. J. Med. Virol. 76:613–618, 2005. © 2005 Wiley‐Liss, Inc.