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The importance of HCV on the burden of chronic liver disease in Italy: A multicenter prevalence study of 9,997 cases
Author(s) -
Sagnelli Evangelista,
Stroffolini Tommaso,
Mele Alfonso,
Almasio Piero,
Coppola Nicola,
Ferrigno Luigina,
Scolastico Carlo,
Onofrio Mirella,
Imparato Michele,
Filippini Pietro
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20313
Subject(s) - medicine , cirrhosis , hbsag , hepatocellular carcinoma , chronic liver disease , liver disease , epidemiology , etiology , gastroenterology , hepatitis c , alcohol abuse , hepatitis c virus , alcoholic liver disease , hepatitis b , risk factor , viral hepatitis , hepatitis b virus , immunology , virus , psychiatry
Knowledge of the current epidemiology of chronic liver disease in Italy is mostly obsolete and fragmentary for the lack of up‐to‐date consistent data. In 2001, a 6‐month prevalence study was undertaken in 79 hospitals to assess the characteristics of chronic liver disease in Italy. Both prevalent and incident cases were enrolled. A total of 9,997 patients were recruited, of whom 939 (9.4%) had normal liver biochemistry, 6,210 (62.1%) had chronic hepatitis, 1,940 (19.4%) had liver cirrhosis, and 341 (3.4%) had hepatocellular carcinoma (HCC). In 567 patients (5.7%) the diagnosis was not established. Hepatitis C virus (HCV) was found in 69.9% of the patients and was the only etiological factor in 56.3% of all the patients. Hepatitis B surface antigen (HBsAg) was present in the serum of 13.4% of the cases (in 10% it was the only etiological factor). A history of alcohol abuse was found in 23% of the cases (9.4% without viral infection). The prevalence of HCV‐related cases was significantly lower in incident than in prevalent cases (44.9% vs. 59.9%, P  < 0.0001), while the proportion of patients with alcohol abuse was much higher in incident than in prevalent cases (18.1% vs. 6.6%, P  < 0.0001). These findings indicate that nearly one quarter of patients with chronic liver diseases in Italy have a severe disease such as liver cirrhosis and HCC represents a not negligible burden for the national health system. Hepatitis B fell in importance as an etiological factor. Hepatitis C is the important pathogenic factor for chronic liver disease in Italy. However, a comparison between the prevalent and incident cases suggests that in future HCV infection will also play a progressively decreasing role, in part as a consequence of treatment. J. Med. Virol. 75:522–527, 2005. © 2005 Wiley‐Liss, Inc.

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