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Inter‐ and intra‐person cytomegalovirus infection in Malawian families
Author(s) -
Beyari Mohammed M.,
Hodgson T.A.,
Kondowe W.,
Molyneux E.M.,
Scully C.,
Porter S.R.,
Teo C.G.
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20312
Subject(s) - virology , cytomegalovirus , cytomegalovirus infections , human cytomegalovirus , viral disease , biology , betaherpesvirinae , medicine , herpesviridae , virus
Sequence polymorphisms in the gN and gO genes of cytomegalovirus (CMV) amplified from mouth rinse and urine samples of 19 Malawian patients with Kaposi's sarcoma (KS) and 58 of their first‐degree relatives were investigated. CMV‐DNA was amplified from 41 people (53%) from either the gN or gO region in at least one sample, from 14 people (18%) in both domains in at least one sample, and from 13 (17%) in either domain in both samples. Twenty‐one (51%) were seropositive for human immunodeficiency virus‐1 (HIV). Identical gN sequences were recovered from eight families and non‐identical sequences in six, while identical gO sequences were found in three families and non‐identical sequences in five. Five people, four of whom were children, each carried multitypic gN sequences or gO sequences. The findings are consistent with CMV spread along intra‐ and extra‐household routes, and with multiple intra‐host CMV infection. J. Med. Virol. 75:575–582, 2005. © 2005 Wiley‐Liss, Inc.