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Detection of human coronavirus NL63 in young children with bronchiolitis
Author(s) -
Ebihara Takashi,
Endo Rika,
Ma Xiaoming,
Ishiguro Nobuhisa,
Kikuta Hideaki
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20289
Subject(s) - bronchiolitis , virology , pneumonia , virus , respiratory tract , respiratory system , coronavirus , respiratory tract infections , medicine , lower respiratory tract infection , biology , respiratory disease , polymerase chain reaction , immunology , covid-19 , gene , lung , disease , infectious disease (medical specialty) , biochemistry
HCoV‐NL63, the fourth human coronavirus, has been isolated recently from children with respiratory tract infections, including upper respiratory infection, bronchiolitis, and pneumonia. The virus has been also detected in immunocompromised adults with respiratory tract infections. A total of 118 nasopharyngeal swab samples from 118 hospitalized young children aged less than 2 years with bronchiolitis who were not infected with human respiratory syncytial virus, influenza A or B, or human metaneumovirus were selected. Three (2.5%) of the 118 samples were positive for HCoV‐NL63 by reverse transcription‐polymerase chain reaction tests. HCoV‐NL63 may be one of the causative agents of bronchiolitis in young children. J. Med. Virol. 75:463–465, 2005. © 2005 Wiley‐Liss, Inc.