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Detection of herpesvirus‐6A in a case of subacute cerebellitis and myoclonic dystonia
Author(s) -
Borghi Elisa,
Pagani Elisabetta,
Mancuso Roberta,
Delbue Serena,
Valli Marilena,
Mazziotti Romina,
Giordano Lucio,
Micheli Roberto,
Ferrante Pasquale
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20285
Subject(s) - dystonia , ataxia , medicine , cerebrospinal fluid , virology , myoclonus , cerebellar ataxia , cerebellum , neurological disorder , pathology , pediatrics , central nervous system disease , anesthesia , psychiatry
This is a case study of a child who developed roseola infantum first, then varicella , and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV‐6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV‐6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies. J. Med. Virol. 75:427–429, 2005. © 2005 Wiley‐Liss, Inc.