Detection of herpesvirus‐6A in a case of subacute cerebellitis and myoclonic dystonia | Zendy

Borghi Elisa | Zendy; Pagani Elisabetta | Zendy; Mancuso Roberta | Zendy; Delbue Serena | Zendy; Valli Marilena | Zendy; Mazziotti Romina | Zendy; Giordano Lucio | Zendy; Micheli Roberto | Zendy; Ferrante Pasquale | Zendy

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Detection of herpesvirus‐6A in a case of subacute cerebellitis and myoclonic dystonia

Author(s) -

Borghi Elisa,

Pagani Elisabetta,

Mancuso Roberta,

Delbue Serena,

Valli Marilena,

Mazziotti Romina,

Giordano Lucio,

Micheli Roberto,

Ferrante Pasquale

Publication year - 2005

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.20285

Subject(s) - dystonia , ataxia , medicine , cerebrospinal fluid , virology , myoclonus , cerebellar ataxia , cerebellum , neurological disorder , pathology , pediatrics , central nervous system disease , anesthesia , psychiatry

This is a case study of a child who developed roseola infantum first, then varicella , and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV‐6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV‐6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies. J. Med. Virol. 75:427–429, 2005. © 2005 Wiley‐Liss, Inc.

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