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Functional variation of HIV‐1 Rev response element in a longitudinally studied cohort
Author(s) -
Phuphuakrat Angsana,
Paris Robert M.,
Nittayaphan Sorachai,
Louisirirotchanakul Suda,
Auewarakul Prasert
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20279
Subject(s) - human immunodeficiency virus (hiv) , cohort , biology , variation (astronomy) , lentivirus , immunology , viral disease , virology , medicine , physics , astrophysics
We showed previously that HIV‐1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV‐1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4 + count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression. J. Med. Virol. 75:367–373, 2005. © 2005 Wiley‐Liss, Inc.