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HCV and HIV co‐infection in pregnant women attending St. Camille Medical Centre in Ouagadougou (Burkina Faso)
Author(s) -
Simpore J.,
Ilboudo D.,
Samandoulougou A.,
Guardo P.,
Castronovo P.,
Musumeci Salvatore
Publication year - 2005
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20258
Subject(s) - medicine , genotype , hepatitis c virus , transmission (telecommunications) , human immunodeficiency virus (hiv) , pregnancy , hepatitis c , virology , immunology , pediatrics , virus , biology , biochemistry , genetics , gene , electrical engineering , engineering
Five hundred and forty‐seven pregnant women with less than 32 weeks of amenorrhoea, attending an antenatal clinic of St. Camille Medical Centre (SCMC) of Ouagadougou were enrolled for a hepatitis C virus (HCV) and HIV co‐infection study. Fifty‐eight (10.6%) were HIV positive and 18 (3.3%) were anti‐HCV positive. Only seven pregnant women (i.e., 1.3%) had a documented HIV and HCV co‐infection. HCV‐RNA was found in 5 out of 18 (27.8%) patients, who had anti‐HCV antibodies. The genotype analysis of these five patients showed that two were of 1b whereas three were of 2a genotype. Mother‐to‐infant transmission of the same HCV genotype (2a) was documented in only one case. High 1b prevalence has been reported in other parts of Africa, while 2a is the prevalent genotype (60%) in Burkina Faso. This genotype has a higher response rate to treatment. Serum transaminases were normal, also in presence of HCV‐RNA. The higher than expected rate of co‐infection in Burkina Faso seems to demonstrate a correlation between these two infections, which could influence the evolution of HIV and HCV diseases. J. Med. Virol. 75:209–212, 2005. © 2004 Wiley‐Liss, Inc.