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Genetic analysis of hepatitis a virus outbreak in france confirms the co‐circulation of subgenotypes Ia, Ib and reveals a new genetic lineage
Author(s) -
CostaMattioli Mauro,
Monpoeho Serge,
Schvoerer Claire,
Besse Bernard,
Aleman MarieHelene,
Billaudel Sylviane,
Cristina Juan,
Ferré Virginie
Publication year - 2001
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.2025
Subject(s) - outbreak , genotype , biology , phylogenetic tree , virology , lineage (genetic) , genetics , genetic analysis , virus , molecular epidemiology , genetic variation , genetic variability , hepatitis a virus , gene
Genetic analysis of selected genome regions of hepatitis A Virus (HAV) suggested that distinct genotype could be defined in different geographic locations. In order to study the degree of genetic variability among HAV isolated during a single epidemic outbreak, sequences from a 148 base pair segment within the VP1 amino terminal region were obtained for eight distinct HAV isolates from an outbreak that occurred in North Bretagne (France). These sequences were compared among themselves and with published sequences from 30 different strains that represented different HAV sub‐genotypes that were isolated all over the world. Phylogenetic analysis revealed an extensive genetic heterogeneity among strains belonging to the same outbreak and revealed co‐circulation of sub‐genotype IA, IB, and the presence of IIIA sub‐genotype for the first time in a Mediterranean country. J. Med. Virol. 65:233–240, 2001. © 2001 Wiley‐Liss, Inc.