Detection of high‐risk HPV types by the hybrid capture 2 test | Zendy

Terry George | Zendy; Ho Linda | Zendy; Londesborough Philip | Zendy; Cuzick Jack | Zendy; MielzynskaLohnas Iwona | Zendy; Lorincz Attila | Zendy

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Detection of high‐risk HPV types by the hybrid capture 2 test

Author(s) -

Terry George,

Ho Linda,

Londesborough Philip,

Cuzick Jack,

MielzynskaLohnas Iwona,

Lorincz Attila

Publication year - 2001

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.2015

Subject(s) - hybrid capture , polymerase chain reaction , virology , pcr test , dna , real time polymerase chain reaction , biology , computational biology , medicine , cervical cancer , genetics , gene , cervical intraepithelial neoplasia , cancer

A hybrid capture test that can be used to detect at least 13 high‐risk HPV types (referred to collectively as HPV‐HR) in cervical scrapes (Hybrid Capture 2 probe set B, HC2‐B) was evaluated. The HC2‐B test is accurate and highly reproducible and the results obtained show excellent agreement with those obtained by a multiplexed type‐specific polymerase chain reaction (mts‐PCR). An additional assay to identify a subset of HPV‐HR types may improve specificity without compromising sensitivity in HC2‐B positive specimens with a test result close to the cut‐off value given by 1 pg/ml HPV DNA. J. Med. Virol. 65:155–162, 2001. © 2001 Wiley‐Liss, Inc.

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