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Limited long‐term naive CD4 + T cell reconstitution in patients experiencing viral load rebounds during HAART
Author(s) -
ChoremiPapadopoulou H.,
Tsalimalma K.,
Dafni U.,
Dimitracopoulou A.,
Kordossis T.
Publication year - 2004
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.20081
Subject(s) - cd8 , cd38 , cd28 , flow cytometry , viral load , lymphocyte subsets , immunology , t lymphocyte , cd4 cd8 ratio , immune system , immunophenotyping , t cell , medicine , virology , human immunodeficiency virus (hiv) , biology , genetics , stem cell , cd34
Abstract Long‐term (3.5 years) immune reconstitution in relation to viral load response was determined. Plasma HIV‐1 RNA was suppressed in 40 patients (full responders) up to 42 months, and 17 patients achieved partial response. The measurements of CD4 + and CD8 + T lymphocyte subsets (CD45RA, CD45RACD62L, CD45RO, CD28, CD38) were carried out by flow cytometry. Full responders had a significant increase of CD4 + and all CD4 + T subsets both up to 6 and from 6 to 42 months, while the increase for partial responders was only up to 6 months. By 6 months, higher slopes were observed in full versus partial responders in the % of CD28 on CD4 + and the % of CD4 + memory subset and in both naïve and memory CD4 + subsets from 6 to 42 months. The percentage of CD8 + and its subsets was decreased significantly in full responders both up to 6 and from 6 to 42 months (except for an increase in the CD8 + CD45RA + CD62L + cells), while in partial responders this decrease was only up to 6 months. Lower slopes were observed in full versus partial responders from 6 to 42 months in the percentages of CD8 + , CD8 + CD45RO + , CD8 + CD28 − , and CD8 + CD38 + T cells. In conclusion, full responders have a stronger long‐term naive CD4 + T cell subset reconstitution than partial responders. J. Med. Virol. 73:235–243, 2004. © 2004 Wiley‐Liss, Inc.