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Detection of several types of human papilloma viruses in AIDS‐associated Kaposi's sarcoma
Author(s) -
Adams Volker,
Kempf Werner,
Hassam Shabbir,
Briner Jakob,
Schmid Mirka,
Moos Rita,
Pfaltz Madeleine
Publication year - 1995
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890460304
Subject(s) - virology , sarcoma , polymerase chain reaction , papilloma , viral disease , kaposi's sarcoma , virus , biology , medicine , pathology , human herpesvirus , gene , genetics
Epidemiological studies indicate that acquired immunodeficiency syndrome (AIDS)‐associated Kaposi's sarcoma (KS) may be caused by an infectious, preferentially sexually transmitted agent. Infections with human papilloma viruses are common, sexually transmitted diseases occurring frequently in homosexual men, who are also the main risk group of developing KS. In order to evaluate the possible role of HPV in the development of KS, 24 cutaneous AIDS‐associated Kaposi's sarcomas were investigated by the polymerase chain reaction (PCR) and by in situ hybridization for the presence of human papilloma viruses (HPV). HPV DNA sequences were detected in 5 of 24 KS specimens, in 4 of 13 normal skin specimens from AIDS patients withoutKS and in 5 of 14 skin specimens of HIV‐seronegative patients. For the first time, HPV types 6 and 33 were detected by PCR in KS. A higher proportion of HPV types 16/18 was found in AIDS‐associated KS specimens, whereas HPV type 33 was seen more often in normal skin specimens of the control group. Apart from the known HPV types 16/18 described in KS, this study demonstrates also the presence of HPV 6 and 33 in this condition. © 1995 Wiley‐Liss, Inc.