Loss of serum HCV RNA at week 4 of interferon‐α therapy is associated with more favorable long‐term response in patients with chronic hepatitis C | Zendy

Orito Etsuro | Zendy; Mizokami Masashi | Zendy; Suzuki Kaoru | Zendy; Ohba KenIchi | Zendy; Ohno Tomoyoshi | Zendy; Mori Masamiki | Zendy; Hayashi Katsuo | Zendy; Kato Koji | Zendy; Iino Shiro | Zendy; Lau Johnson Y. N. | Zendy

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Loss of serum HCV RNA at week 4 of interferon‐α therapy is associated with more favorable long‐term response in patients with chronic hepatitis C

Author(s) -

Orito Etsuro,

Mizokami Masashi,

Suzuki Kaoru,

Ohba KenIchi,

Ohno Tomoyoshi,

Mori Masamiki,

Hayashi Katsuo,

Kato Koji,

Iino Shiro,

Lau Johnson Y. N.

Publication year - 1995

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890460205

Subject(s) - medicine , interferon , gastroenterology , hepatitis c virus , chronic hepatitis , immunology , alpha interferon , flaviviridae , hepatitis c , interferon alfa , virus , virology

To determine the virological factors associated with a favorable long‐term response to interferon‐α (IFN) therapy in chronic hepatitis C virus (HCV) infection, 61 Japanese patients with chronic HCV infection were treated with IFN for 24 weeks (780 million units in total) and followed for 8 to 16 months after cessation of therapy. Ten patients dropped out because of severe side effects. Of the 51 patients who completed IFN therapy, 23 showed complete and sustained response (CR→SR), 13 complete response with early relapse (CR→Rel), and 15 no response to IFN (NR). For the pretreatment serum HCV RNA level, 20/23 who had CR→SR had

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