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Hepatitis C virus type I(1a) in Northern China
Author(s) -
Niu Junqi,
Kumar Umesh,
Pan Yu,
Liu Yuanyuan,
Zhan Qingquan,
Thomas Howard,
Monjardino John
Publication year - 1995
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890460113
Subject(s) - virology , genotype , hepatitis c virus , flaviviridae , biology , antibody , virus , reverse transcriptase , typing , hepacivirus , polymerase chain reaction , concordance , viral disease , reverse transcription polymerase chain reaction , gene , immunology , genetics , messenger rna
Twenty‐four patients with hepatitis C virus (HCV) antibody from the Chinese North Western province of Jilin were further analysed by the immunoblot assay‐2 (RIBA‐2). reverse transcription‐polymerase chain reaction (RT‐PCR) for serum HCV RNA detection, and direct sequence‐geno‐typing. Good concordance was found between the original second generation HCV antibody ELISA, RIBA‐2, and serum HCV RNA. The occurrence of genotype I (la), a genotype not previously reported in China, is described in 5(20.8%) of 24 cases, in association with genotypes II(1b) and III(2a) which were found in 16(66.7%) and 3(12.5%) of 24 cases, respectively. Imported blood products were unlikely to be the source of infection with genotype I (1a) but could not be definitively ruled out. © 1995 Wiley‐Liss, Inc.