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Phylogenetically distinct hantavirus implicated in a case of hantavirus pulmonary syndrome in the Northeastern United States
Author(s) -
Hjelle Brian,
Krolikowski John,
TorrezMartinez Norah,
ChavezGiles Francesca,
Vanner Cynthia,
Laposata Elizabeth
Publication year - 1995
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890460106
Subject(s) - hantavirus , hantavirus pulmonary syndrome , virology , hantavirus infection , virus , bunyaviridae , biology
Hantavirus pulmonary syndrome (HPS) is an acute respiratory illness with high mortality. It is caused by a newly described New World hantavirus known as Four Corners virus (FCV). Nearly all cases of HPS have occurred in the western United States. The etiologic agents in those cases have been closely related to each other, based upon comparisons of their genetic sequences. We have molecularly cloned the S genomic segment of a hantavirus (RI‐1) implicated in a case on HPS in the northeastern United States. Nucleotide sequence analysis shows that the RI‐1 virus has many similarities to FCV, but is clearly distinct from the western forms of that virus. These data suggest that HPS can be caused by multiple agents that together form a distinctive evolutionary cIade. © 1995 Wiley‐Liss, Inc.