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Precore and core mutations in HBV from individuals in india with chronic infection
Author(s) -
Valliammai T.,
Harrison Tim J.,
Zuckerman Arie J.,
Thyagarajan S. P.
Publication year - 1995
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890450315
Subject(s) - virology , biology , core (optical fiber) , medicine , computer science , telecommunications
Ten hepatitis B surface antigen seropositive carriers (5 asymptomatic and 5 with chronic liver disease) were tested for HBeAg/anti‐HBe and for HBV‐DNA using the polymerase chain reaction. Five were DNA‐positive, 2 with HBeAg and 3 with anti‐HBe. Nucleotide sequences were determined for these 5 cases. Hepatitis B virus DNA from one cirrhotic carrier with anti‐HBe had a mutation in the precore region (nucleotide position 1862) which may affect signal peptide cleavage and HBeAg synthesis. In the other 2 anti‐HBe‐ and DNA‐positive cases, a cirrhotic carrier and an asymptomatic case, there was a mutation at nucleotide position 1896 leading to a termination codon in the precore region. In all 5 patients, except for one or two missense mutations, there was no significant variation in the core region. © 1995 Wiley‐Liss, Inc.