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Immunogenicity and safety in adults of hepatitis A virus vaccine administered as a single dose with a booster 6 months later
Author(s) -
Briem H.,
Safary A.
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890440424
Subject(s) - immunogenicity , booster dose , hepatitis a vaccine , medicine , booster (rocketry) , vaccination , virology , hepatitis a , age groups , virus , immunology , hepatitis , antibody , titer , demography , physics , astronomy , sociology
An inactivated vaccine against hepatitis A was administered as a single 1,440 enzyme‐linked immunosorbent assay (ELISA) units dose at month 0 with a booster at month 6 to 200 subjects divided into two age groups: group 1, 20–39 years (n = 134) and group II, 40–62 years (n = 66). At day 15, the seropositivity rates were 90% and 77% in groups I and II, respectively. At month 1 the seropositivity rate was 97% in both groups. At month 6 the seropositivity rates were 94% and 88% in groups I and II, respectively. One month after the booster, at month 7, 100% in both groups had become seropositive. The vaccine was well tolerated and did not cause any severe reactions. The results indicate that a single high vaccine dose offers protection against hepatitis A virus (HAV) for at least 6 months in the majority of cases where rapid vaccination is required even in travellers of older age. A booster dose will ensure long‐term protection. © 1994 Wiley‐Liss, Inc.