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Antibody response to adenovirus Elb‐derived synthetic peptides and serum levels of p53 in patients with gastrointestinal and other malignant lymphomas
Author(s) -
Lähdeaho M.L.,
Lehtinen T.,
Aine R.,
Hakala T.,
Lehtinen M.
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890430413
Subject(s) - lymphoma , antibody , immunology , malignant lymphoma , biology , concomitant , medicine , virology
Abstract Serum levels of p53 and antipeptide antibody levels to adenovirus type 12 (Ad12) E1b protein were measured in a case‐control study of 62 newly diagnosed patients with malignant lym‐phoma. While patients with gastrointestinal lym‐phoma did not differ from their matched controls, p53 positive lymphoma patients had significantly ( P < 0.04) increased antipeptide IgG antibody levels to the Ad12 E1b. Concomitant detection of serum p53 and antipeptide antibodies to Ad 12 E1b was associated with an increased risk (OR = 17.0, 95% confidence limits 1.5, 58.5) of malignant lymphoma suggesting synergism between expression of Ad12 Elb and accumulation of p53 in patients with malignant lymphoma. © 1994 Wiley‐Liss, Inc.