Tumor necrosis factor, interleukin‐2, and interferon‐gamma in adult varicella | Zendy

Wallace Mark R. | Zendy; Woelfl Ingrid | Zendy; Bowler William A. | Zendy; Olson Patrick E. | Zendy; Murray Nancy B. | Zendy; Brodine Stephanie K. | Zendy; Oldfield Edward C. | Zendy; Arvin Ann M. | Zendy

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Tumor necrosis factor, interleukin‐2, and interferon‐gamma in adult varicella

Author(s) -

Wallace Mark R.,

Woelfl Ingrid,

Bowler William A.,

Olson Patrick E.,

Murray Nancy B.,

Brodine Stephanie K.,

Oldfield Edward C.,

Arvin Ann M.

Publication year - 1994

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890430113

Subject(s) - medicine , tumor necrosis factor alpha , rash , immunology , interferon , encephalitis , interferon gamma , interleukin , pneumonia , virology , cytokine , gastroenterology , virus

Adult varicella can be a severe illness complicated by pneumonia, encephalitis, or prolonged fever. This study measured levels of tumor necrosis factor (TNF)‐alpha, interleukin‐2 (IL‐2), and interferon gamma (IFN‐G) in a consecutive group of 31 adult varicella patients presenting within 24 hours of rash onset. All cytokines were assayed using an ELISA technique. TNF‐alpha was detectable in 71% of patients with a mean level of 52 pg/ml. IL‐2 was detectable in 29% with a mean level of 1040 pg/ml. IFN‐gamma was detectable in only 9%. There was no correlation between TNF, IL‐2, or IFN‐G level and clinical severity as determined by duration and severity of cutaneous findings, duration of fever, frequency of hepatitis, or thrombocytopenia. © 1994 Wiley‐Liss, Inc.

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