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Tumor necrosis factor, interleukin‐2, and interferon‐gamma in adult varicella
Author(s) -
Wallace Mark R.,
Woelfl Ingrid,
Bowler William A.,
Olson Patrick E.,
Murray Nancy B.,
Brodine Stephanie K.,
Oldfield Edward C.,
Arvin Ann M.
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890430113
Subject(s) - medicine , tumor necrosis factor alpha , rash , immunology , interferon , encephalitis , interferon gamma , interleukin , pneumonia , virology , cytokine , gastroenterology , virus
Adult varicella can be a severe illness complicated by pneumonia, encephalitis, or prolonged fever. This study measured levels of tumor necrosis factor (TNF)‐alpha, interleukin‐2 (IL‐2), and interferon gamma (IFN‐G) in a consecutive group of 31 adult varicella patients presenting within 24 hours of rash onset. All cytokines were assayed using an ELISA technique. TNF‐alpha was detectable in 71% of patients with a mean level of 52 pg/ml. IL‐2 was detectable in 29% with a mean level of 1040 pg/ml. IFN‐gamma was detectable in only 9%. There was no correlation between TNF, IL‐2, or IFN‐G level and clinical severity as determined by duration and severity of cutaneous findings, duration of fever, frequency of hepatitis, or thrombocytopenia. © 1994 Wiley‐Liss, Inc.