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Inhibition of human immunodeficiency virus type 1 replication by nonionic block polymer surfactants
Author(s) -
Hirschman Shalom Z.,
Zucker Marcia L.,
Garfinkel Esther
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890420309
Subject(s) - viral replication , copolymer , replication (statistics) , virology , human immunodeficiency virus (hiv) , in vitro , virus , chemistry , biology , polymer , biochemistry , organic chemistry
Abstract Eight block copolymers of hydrophilic polyoxy‐ethylene and hydrophobic polyoxypropylene were examined for their effects on the replication of human immunodeficiency virus type 1 (HIV‐1) in H9 cells. Although the polymers decreased cellular replication, they did not appear to be toxic to the cells; rather, they seemed to arrest cellular growth. Three triblock copolymers were found to inhibit HIV replication at low concentrations. Maximum inhibition was achieved at concentrations of 50 μUg/ml by day 5 following infection. The combination of azidothymidine with both HIV‐1‐inhibitory and noninhibitory copolymers resulted in antagonistic effects, with an increase in viral replication, compared to treatment with copolymers or azidothymidine alone. These copolymers should be useful in the study of the mechanism of HIV replication in cell cultures and may yield clinically useful compounds in combination therapies for HIV infection. © 1994 Wiley‐Liss, Inc.