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Dengue virus infects mouse cultured neurons but not astrocytes
Author(s) -
Imbert Jose Luis,
Guevara Patricia,
RamosCastañeda Jose,
Ramos Celso,
Sotelo Julio
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890420304
Subject(s) - virology , dengue virus , virus , immunofluorescence , biology , dengue fever , antibody dependent enhancement , cell culture , flavivirus , antibody , immunology , genetics
Cultures of mouse brain cells containing a high proportion either neurons or astrocytes were inoculated with various strains of dengue virus. At analysis by double immunofluorescence, all strains of dengue virus studied were tropic for neurons. In no case were the astrocytes infected. Only ∼10% of all neurons were infected, suggesting that the virus may enter the cell through a membrane receptor present only in a subgroup of neurons. © 1994 Wiley‐Liss, Inc.