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Molecular epidemiological studies of human herpesvirus 6 in families
Author(s) -
Mukai Tetsu,
Yamamoto Takeshi,
Kondo Toshio,
Kondo Kazuhiro,
Okuno Toshiomi,
Kosuge Haruhiko,
Yamanishi Koichi
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890420303
Subject(s) - virology , biology , molecular epidemiology , epidemiology , human herpesvirus 6 , restriction enzyme , saliva , transmission (telecommunications) , genetics , human herpesvirus , herpesviridae , peripheral blood , viral disease , genotype , virus , dna , gene , medicine , immunology , biochemistry , electrical engineering , engineering
The mode of transmission of human herpesvirus 6 (HHV‐6) was investigated by molecular epidemiological techniques in four families. HHV‐6 was isolated from the peripheral blood of seven infants with exanthem subitum, including siblings, and from the saliva of two mothers. These isolates were examined for genetic relatedness by means of restriction enzymes analysis of purified DNA. While the profiles of the digestion patterns differed among families, they were very similar in a particular family. These results may suggest that HHV‐6 is transmitted primarily from mother to child. © 1994 Wiley‐Liss, Inc.