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Chronic liver disease in Peru: Role of viral hepatitis
Author(s) -
Barhani William B.,
Figueroa Rolando,
Phillips Irving A.,
Hyams Kenneth C.
Publication year - 1994
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890420206
Subject(s) - hepatocellular carcinoma , medicine , hbsag , cirrhosis , chronic liver disease , liver disease , liver biopsy , hepatitis c , hepatitis , viral hepatitis , hepatitis c virus , population , hepatitis b , viral disease , gastroenterology , immunology , virology , hepatitis b virus , biopsy , virus , environmental health
The prevalence of antibodies to hepatitis C virus (anti‐HCV) was determined in 105 patients with biopsy‐proven chronic liver disease and 128 comparison patients without any evidence of liver pathology living in Lima, Peru. Using a second‐generation EIA screening and supplemental immunoblot assay, anti‐HCV was detected in four of 13 patients with chronic hepatitis, in 11% of 85 patients with cirrhosis, and in none of seven patients with hepatocellular carcinoma. Only two (1.6%) comparison patients without liver disease had anti‐HCV. Hepatitis B surface antigen (HBsAg) was found in 23% of patients with chronic hepatitis, 12% of patients with cirrhosis, and three of seven patients with hepatocellular carcinoma. There was no evidence of chronic viral hepatitis or alcohol abuse (reported by one‐third of subjects) in 48% of chronic liver disease patients. These preliminary data suggest that among this South American population neither hepatitis B nor hepatitis C infection is the predominate cause of chronic liver disease and that other infectious or environmental factors may be important. © 1994 Wiley‐Liss, Inc.