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Effect of oral acyclovir on pain resolution in herpes zoster: A reanalysis
Author(s) -
Huff J. Clark,
Drucker J. L.,
Clemmer A.,
Laskin O. L.,
Connor J. D.,
Bryson Y. J.,
Balfour H. H.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890410518
Subject(s) - postherpetic neuralgia , medicine , placebo , neuralgia , exanthem , chronic pain , varicella zoster virus , zona , anesthesia , aciclovir , dermatology , virus , viral disease , herpesviridae , neuropathic pain , virology , physical therapy , pathology , alternative medicine
The most frequent complication of herpes zoster is postherpetic neuralgia, usually defined as chronic pain in the area of the exanthem that persists for at least a month after the skin lesions have healed. Several clinical studies of acyclovir showed a reduction in severity and duration of acute pain, but provided no definitive data for chronic pain. In order to determine if acyclovir therapy could reduce chronic pain, we reanalyzed data from the largest U.S. placebo‐controlled treatment trial of 187 immunocompetent persons with herpes zoster. By considering pain as a continuum, we found that the median duration of pain in acyclovir recipients was 20 days vs. 62 days for their placebo counterparts ( P = 0.02). Thus, acyclovir has been shown to reduce chronic zoster‐associated pain. We also noted that the absence of pain at the onset of cutaneous herpes zoster did not preclude its later development.