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BK virus infection of the human urinary tract
Author(s) -
Shinohara Toshiya,
Matsuda Michiyuki,
Cheng Seng H.,
Marshall John,
Fujita Miri,
Nagashima Kazuo
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890410408
Subject(s) - bk virus , virus , virology , jc virus , monoclonal antibody , renal pelvis , urinary system , antibody , biology , antigen , polyomavirus infections , kidney , immunology , progressive multifocal leukoencephalopathy , kidney transplantation , endocrinology
By screening consecutive autopsy cases with an antibody that recognizes human polyomaviruses, we found a case of malignant lymphoma in which the virus infection was confined to epithelia of the renal calyces, renal pelvis, ureter, and urinary bladder. The virus was confirmed as BK virus by a specific monoclonal antibody against BK virus T antigen, and numerous virus particles were identified by electron microscopy. The results showed that BK virus is a human urotheliotrophic virus.