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Administration of inactivated and detergent‐treated influenza virus to mice before virus challenge reduces mortality
Author(s) -
Arora D. J. S.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890410117
Subject(s) - virus , virology , nasal administration , titer , immunity , lethal dose , biology , medicine , microbiology and biotechnology , immune system , immunology , toxicology
Formalin‐inactivated virus (FIV) and the detergent‐treated virus (DTV) preparations were tested for their ability to enhance the resistance of mice to experimental influenza infection. FIV (100 μg) was administered intravenously to mice. After 24 hr, animals were challenged with 5 LD50 dose intranasally. FIV‐treated and nontreated (control) mice had 10% and 100% mortality, respectively. Similar results were obtained with the DTV (40 μg) preparation. The pulmonary virus titer of FIV‐treated mice was lower when compared with the control. Mechanisms other than acquired immunity may have conferred the early resistance to virus infection in mice.