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The E2 region of HPV 16 in relation to different types of cervical lesions
Author(s) -
Krajinovic Maja,
Lazic Jelena,
Stanimirovic Branko,
Diklic Vukosava,
Savic Ana
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890410102
Subject(s) - polymerase chain reaction , virology , gene , biology , medicine , pathology , genetics
The presence of the E2 region of HPV 16 was determined by the polymerase chain reaction in biopsy samples with different histopathological diagnoses. The absence of the E2 gene was observed in 17 of 30 cases examined. The E2 deletions were not confined exclusively to invasive carcinomas or to integrated viral forms. In the majority of cases, the course of cervical lesions was consistent with the state of the E2 gene.