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Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection
Author(s) -
Chau Kurt H.,
Dawson George J.,
Bile Khalif M.,
Magnius Lars O.,
Sjogren Maria H.,
Mushahwar Isa K.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890400414
Subject(s) - virology , virus , antibody , hepatitis a virus , hepatitis e virus , hepatitis , medicine , biology , immunology , gene , genotype , biochemistry
A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti‐HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti‐HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan. © 1993 Wiley‐Liss, Inc.