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Infection of human fetal dorsal root neurons with wild type varicella virus and the Oka strain varicella vaccine
Author(s) -
Somekh Eli,
Levin Myron J.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890400313
Subject(s) - virology , biology , strain (injury) , virus , fetus , microbiology and biotechnology , pregnancy , genetics , anatomy
The relative ability of a varicella‐zoster virus (VZV) clinical isolate and a live attenuated VZV vaccine strain (Oka) to infect human neurons was determined in vitro. VZV infection of neurons prepared in culture from dorsal root ganglia of fetuses was assessed using an infectious center assay. Cultures were infected with 50–5,000 pfu of either VZV and assayed at either 24 or 48 hours post‐VZV infection. Cultures infected with the clinical VZV isolate had seven‐fold more infected neurons than cultures infected with the vaccine strain VZV. © 1993 Wiley‐Liss, Inc.