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Nine‐year follow‐up study of a plasma‐derived hepatitis B vaccine in a rural African setting
Author(s) -
Tabor Edward,
Cairns James,
Gerety Robert J.,
Bayley Anne C.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890400307
Subject(s) - medicine , serology , hepatitis b vaccine , antibody , vaccination , virology , hepatitis b , hepatitis b virus , immunology , virus , hbsag
One hundred and one of 255 recipients of a plasma‐derived hepatitis B vaccine were evaluated in 1990, 9 years after the first vaccine dose in a study in Zambia to evaluate the efficacy of one, two, or three doses. In 1983, 2 years after the first vaccine dose, antibody to the hepatitis B surface antigen (anti‐HBs) had been detectable in 90 of these 101 participants (89%). In 1990, anti‐HBs was still detectable in 72 of 101 (71%), and was present at a protective level ( ≥ 10 mlU ml) in 68 of 101 (67%). Although the original vaccine study elicited a protective level of antibody in a greater percentage of children and adolescents than in adults, there were no significant differences among the three groups at 9 years. (In 1990, anti‐HBs was still detectable in 52 of 70 [74%] who had had no serologic markers of the hepatitis B virus in 1981, and a protective level was detected in 47 of 70 [67%].) A protective level of anti‐HBs was detected in 1990 in 26 of 36 (72%) recipients of three doses and in 23 of 31 (74%) recipients of two doses; the slightly lower prevalence among recipients of one dose (19 of 34 [56%]) was not statistically significant. However, between the years 1983–1990, hepatitis B virus infections had occurred in one of 36 (3%) of those who had been vaccinated with three doses, one of 31 (3%) vaccinated with two doses, and eight of 34 (24%) of those vaccinated with one dose ( P < .02 for either two or three doses compared with one dose). These data support the long‐term immunogenicity and protective efficacy of a two‐ or three‐dose regimen of the hepatitis B vaccine in a rural African setting. © 1993 Wiley‐Liss, Inc.