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Aetiology of acute sporadic non‐A, non‐B viral hepatitis in India
Author(s) -
Arankalle V. A.,
Chobe L. P.,
Jha J.,
Chadha M. S.,
Banerjee K.,
Favorov M. O.,
Kalinina T.,
Fields H.
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890400208
Subject(s) - virology , viral hepatitis , hepatitis , hepatitis e virus , viral disease , polymerase chain reaction , etiology , medicine , hepatitis a , acute hepatitis , hepatitis c , immunology , biology , genotype , virus , gene , biochemistry
Non‐A, non‐B (NANB) hepatitis viruses are now classified as hepatitis E (enterically transmitted) and hepatitis C (parenterally transmitted). India experiences a large number of epidemics of the enteric disease every year. In addition, about 70% of the sporadic cases among adults are also due to NANB hepatitis. With the availability of an immunoblot assay for the detection of anti‐HEVIgM and the polymerase chain reaction (PCR) for the detection of HCV‐RNA, serum samples from epidemic and sporadic NANB patients were screened for these markers. We found that a large number of cases from the epidemics were HEV, though a few remained undiagnosed, while of the sporadic cases only a few could be diagnosed as HCV or HEV; a large proportion remained undiagnosed. © 1993 Wiley‐Liss, Inc.