Comparative study of the isolation of human immunodeficiency virus from the lung and peripheral blood of aids patients | Zendy

Clarke John R. | Zendy; Williamson John D. | Zendy; Mitchell David M. | Zendy

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Comparative study of the isolation of human immunodeficiency virus from the lung and peripheral blood of aids patients

Author(s) -

Clarke John R.,

Williamson John D.,

Mitchell David M.

Publication year - 1993

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890390304

Subject(s) - bronchoalveolar lavage , virology , pneumocystis carinii , pneumonia , virus , lung , polymerase chain reaction , cytomegalovirus , medicine , immunology , viral disease , concomitant , biology , human immunodeficiency virus (hiv) , herpesviridae , pneumocystis jirovecii , biochemistry , gene

HIV-1 proviral DNA was detected by the polymerase chain reaction (PCR) in leucocytes from the peripheral blood (PBL) and bronchoalveolar lavage (BAL) of 100% and 72%, respectively, of HIV-1 seropositive patients. Infective virus isolated by cocultivation was recovered from the PBL and BAL of 50% and 59% of individuals, respectively. Isolation of HIV-1 was more readily made from the lung of individuals undergoing Pneumocystis carinii pneumonia (PCP) than from patients with non-PCP lung infections. The concomitant infection of lung cells with cytomegalovirus did not affect the isolation rate of HIV-1 from the lung. HIV-1 was isolated from BAL of 23 out of 36 (64%) individuals receiving no antiviral chemotherapy and from 13 out of 24 (54%) patients who were receiving AZT.

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