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Identification and use of a neutralizing epitope of parvovirus b19 for the rapid detection of virus infection
Author(s) -
Loughrey Ann C.,
O'Neill Hugh J.,
Coyle Peter V.,
Deleys Robert
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890390204
Subject(s) - northern ireland , virus , parvovirus , history , library science , virology , medicine , ethnology , computer science
A conserved neutralising epitope was confirmed as the site of specific activity for the monoclonal antibody R92F6. This monoclonal antibody was used to detect B19 viral antigen in serum samples after SDS-PAGE and Western blotting. Twenty samples from the United Kingdom, Ireland, Japan, and the United States were positive with this technique. Serum samples from various control groups were negative.