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Comparative study of human and rabbit cell infection with cell‐free HTLV‐I
Author(s) -
Yamade Ichiro,
Isono Takahiro,
Ishiguro Tatsuya,
Yoshida Yoshinobu
Publication year - 1993
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890390114
Subject(s) - virology , virus , rabbit (cipher) , cell culture , cell , biology , human cell , genetics , statistics , mathematics
Infection of human and rabbit cells with cell-free HTLV-I was studied by PCR analysis. Both human and rabbit PBL were infected similarly by cell-free virus of both human and rabbit cell origin. Cells were infected with the cell-free virus without prior treatment and regardless of the concentration of the culture supernatant containing the virus. Human and rabbit cell lines were also infected similarly by the cell-free virus, the proviral DNA persisting for more than two months. The culture supernatants of HTLV-I-producing cells could thus be a potential cause of laboratory infections.