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Evidence for T‐cell involvement during the acute phase of echo virus meningitis
Author(s) -
Lucht Frédéric,
Cordier GenevièVe,
Pozzetto Bruno,
Frésard Anne,
Revillard JeanPierre
Publication year - 1992
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890380204
Subject(s) - echovirus , cerebrospinal fluid , enterovirus , immunology , immune system , meningitis , virus , neopterin , virology , antigen , t cell , biology , cell , cellular immunity , peripheral blood mononuclear cell , medicine , pathology , biochemistry , genetics , psychiatry , in vitro
Little is known about the cellular immune response during the acute phase of enterovirus infection. This was studied in patients with echovirus meningitis by analysing changes in the lymphocyte subset distribution both in blood and in cerebrospinal fluid (CSF) and their stage of activation. A significant increase of whole T‐cell and CD4 + T‐cell counts was observed in CSF in parallel with a slight decrease of T‐cell percentage in blood. Activation of the cellular immune response is supported by the observation of elevated neopterin levels in serum and CSF. However, the phenotypic markers of T‐cell activation, IL‐2 receptor (CD251, and HLA‐DR antigens were not detected in blood or in CSF. © 1992 Wiley‐Liss, Inc.