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Donated organ as a source of cytomegalovirus in orthotopic liver transplantation
Author(s) -
Sutherland Sheena,
Bracken Paul,
Wreghitt Tim G.,
O'Grady John,
Calne Roy Y.,
Williams Roger
Publication year - 1992
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890370304
Subject(s) - asymptomatic , cytomegalovirus , medicine , antibody , organ transplantation , transplantation , betaherpesvirinae , immunology , liver transplantation , viral disease , herpesviridae , virology , virus
The importance of the donated organ as a source of CMV was assessed in 120 patients following orthotopic liver transplant and the CMV infections that developed in these patients were graded by severity. Forty‐four recipients were CMV antibody negative pre‐transplant. Eighteen of these received organs from CMV antibody positive donors and 15 (83%) developed primary CMV infections, 13 (87%) of which were symptomatic. Twenty‐six received organs from CMV antibody negative donors and only 2 (8%) became CMV positive post transplant ( P < 0.001). These data suggest that there would be a considerable advantage in matching CMV antibody negative recipients with negative donors. Forty‐five percent of secondary infections were asymptomatic compared with 12% of primary infections, and only 11% became disseminated compared with 53% of primary infections. The secondary infections that followed transplantation of an organ from a CMV antibody positive donor were more likely to be symptomatic and were more severe than those in patients who received seronegative livers. © 1992 Wiley‐Liss, Inc.