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Prevalence of antibodies to recombinant virion infectivity factor in the sera of prospectively studied patients with HIV‐1 infection
Author(s) -
Schwander S.,
Braun R. W.,
Kühn J. E.,
Hufert F. T.,
Kern P.,
Dietrich M.,
Wieland U.
Publication year - 1992
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890360212
Subject(s) - infectivity , virology , antibody , recombinant dna , viral disease , biology , lentivirus , human immunodeficiency virus (hiv) , virus , immunology , medicine , gene , biochemistry
Two hundred twenty‐four sera were collected from 34 HIV‐1 infected patients during an observation period of up to 4.5 years (109 patient years of observation). The sera were tested for the presence of antibodies against the HIV‐1 virion infectivity factor (vif) protein. Thirty sera from 6 HIV‐1 seronegative individuals served as negative controls. The sera were immunoblotted against a recombinant, prokaryotically expressed vif protein. The prevalence of anti‐vif antibodies increased significantly with progression of the disease from 18% to 81% ( P < 0.0001) which suggests a possible role of vif in HIV‐1 replication and pathogenicity.