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Quantitation of HIV: Correlation with clinical, virological, and immunological status
Author(s) -
O'Shea Siobhan,
Rostron Timothy,
Hamblin Anne S.,
Palmer Sara J.,
Banatvala Jangu E.
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890350114
Subject(s) - asymptomatic , virology , antibody , immunology , viral load , medicine , antigen , viral disease , beta 2 microglobulin , gp41 , asymptomatic carrier , immunopathology , human immunodeficiency virus (hiv) , biology , epitope
Abstract A quantitative assay has been used to measure titres of infectious HIV in peripheral blood of symptomatic and asymptomatic patients. Viral titres were assessed in conjunction with virological and immunological status of patients including measurement of p24 antigen, antibody responses to structural (gp41, p24) and regulatory gene products (NEF, REV, TAT, and VIF), determination of beta 2 microglobulin levels and enumeration of lymphocyte subsets. Titres of HIV were significantly higher among symptomatic than asymptomatic patients. Viral load was closely associated with the number of CD4 + cells, the proportion of these cells harbouring HIV increasing with disease progression. Higher titres of infectious HIV among symptomatic patients was also associated with p24 antigenaemia and decreased antibody responses to NEF.