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Persistence of HIV‐1 silent infection in seronegative subjects at high risk
Author(s) -
Pezzella Mario,
Rosci Maria A.,
Miceli Michela,
Vonesch Nicoletta,
Sturchio Elena,
Mirolo Marina,
Mannella Emilio
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890350104
Subject(s) - virology , persistence (discontinuity) , viral disease , virus , human immunodeficiency virus (hiv) , antibody , sida , biology , immunopathology , lentivirus , medicine , immunology , geotechnical engineering , engineering
Twenty regular sexual partners of HIV‐1 infected subjects, without detectable human irnmunodeficiency virus (HIV‐1) antibody and positive for HIV‐1 genome by in situ hybridization (ISH), were selected and studied longitudinally for 6–36 months to estimate the duration of silent infection. During the follow‐up period, 10 showed atypical Western Blot (WB) patterns. Two seronegative partners seroconverted. Rapid progress t o AIDS was observed in 7 seropositive subjects.