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Antibody response to the immediate early protein of cytomegalovirus in renal transplant recipients
Author(s) -
Shiraki Kimiyasu,
Ishibashi Michio,
Okuno Toshiomi,
Yamanishi Koichi,
Takahashi Michiaki,
Tanaka Kazuko,
Baba Koichi,
Yabuuchi Hyakuji,
Kokado Yukito,
Takahara Siro,
Sonoda Takao
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890340413
Subject(s) - cytomegalovirus , antibody , medicine , betaherpesvirinae , immunology , antibody response , renal function , virology , renal transplant , isolation (microbiology) , transplantation , herpesviridae , viral disease , biology , virus , bioinformatics
The antibody response to the immediate early protein (IEP) of cytomegalovirus (CMV) was examined in seven renal transplant recipients during CMV reactivation and associated clinical abnormalities. Three cases with antibody increase to the IEP in the week after CMV isolation had no CMV‐induced disease. The four patients without antibody increase exhibited laboratory abnormalities and three of them had renal dysfunction. In this small number of patients, the antibody response to the IEP in the week after isolation of CMV was associated with absence of abnormal clinical laboratory findings including renal function, and the prognosis was good for graft function in renal transplant recipients with CMV reactivation.