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Detection of two antigenic subpopulations of A(H1N1) influenza viruses from pigs: Antigenic drift or interspecies transmission?
Author(s) -
Donatelli I.,
Campitelli L.,
Castrucci M. R.,
Ruggieri A.,
Sidoli L.,
Oxford J. S.
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890340410
Subject(s) - virology , biology , antigenic drift , h5n1 genetic structure , antigenic shift , antigen , serology , antigenic variation , virus , influenza a virus subtype h5n1 , original antigenic sin , orthomyxoviridae , influenza a virus , antibody , genetics , covid-19 , infectious disease (medical specialty) , medicine , disease , pathology
Serological analysis of a group of 63 influenza H1N1 viruses isolated from pigs in Italy in the period 1976–1988 revealed the presence of two distinct antigenic subpopulations: some viruses possessed a haemagglutinin indistinguishable from that of viruses typically associated with pigs, i.e., A/New Jersey/8/76 (H1N1), whereas others showed a close antigenic relatedness with the haemagglutinin of avian‐like HI viruses. These findings represent further evidence that influenza A viruses from avian species may be transmitted to mammals. The surface and internal proteins of some of these viruses were also analyzed biochemically to evaluate the molecular relatedness among viruses circulating in nonhuman hosts.