Hepatitis C viraemia in adults with type 2 autoimmune hepatitis | Zendy

Garson J. A. | Zendy; Lenzi M. | Zendy; Ring C. | Zendy; Cassani F. | Zendy; Ballardini G. | Zendy; Briggs M. | Zendy; Tedder R. S. | Zendy; Bianchi F. B. | Zendy

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Hepatitis C viraemia in adults with type 2 autoimmune hepatitis

Author(s) -

Garson J. A.,

Lenzi M.,

Ring C.,

Cassani F.,

Ballardini G.,

Briggs M.,

Tedder R. S.,

Bianchi F. B.

Publication year - 1991

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890340405

Subject(s) - hepatitis c virus , virology , hepatitis c , autoimmune hepatitis , antibody , primary biliary cirrhosis , immunology , medicine , flaviviridae , hepatitis , viral disease , pathogenesis , hepacivirus , recombinant dna , virus , biology , gene , biochemistry

Sera from 14 patients with type 2 autoimmune hepatitis (anti‐LKM, positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and “in‐house” ELlSAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti‐HCV positive patients were shown to be viraemic by a polymerase chain reaction‐based assay for serum HCV RNA. Neither anti‐HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.

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