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Seroepidemiology of human herpesvirus‐6 in pregnant women from different parts of the world
Author(s) -
Ranger S.,
Patillaud S.,
Denis F.,
Himmich A.,
Sangare A.,
M'Boup S.,
ItouaN'Gaporo A.,
PrinceDavid M.,
Chout R.,
Cevallos R.,
Agut H.
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890340313
Subject(s) - martinique , titer , population , indirect immunofluorescence , serology , virology , geography , antibody , medicine , demography , biology , immunology , virus , environmental health , west indies , ethnology , history , sociology
The prevalence of HHV‐6 IgG was studied in 11 different countries across several continents: Morocco, Burkina‐Faso, Congo, Ivory Coast, Mali, Niger, Senegal, Togo, Ecuador, Martinique, and France. The study group consisted of 550 pregnant women, representative of the general adult population in each country. Antibodies were detected by immunofluorescence assay on HSB‐2 cells infected with HHV‐6. Each serum was tested at nine dilutions (1:20 to 1:5,120), sera ≥20 being considered positive. For the HSB‐2 cells. Great differences were seen between separate areas: Morocco showed both low prevalence (20%) and a low geometric mean titer (12), whereas sub‐Saharan Africa displayed high prevalences (60% to 90%) and variable geometric mean titers (34 to 229). This study revealed a prevalence of 92% for Ecuador, signifcantly higher than the prevalence for Martinique (50%), yet both countries had very low antibody titers compared with those found in Africa. The prevalence in France (76%) was similar to previous results from other European countries.