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Chronic fatigue syndrome: Lack Of association with hepatitis C virus infection
Author(s) -
Dale Janet K.,
Di Bisceglie Adrian M.,
Hoofnagle J. H.,
Straus Stephen E.
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890340209
Subject(s) - chronic fatigue syndrome , medicine , etiology , hepatitis c virus , immunology , chronic hepatitis , virus , seroprevalence , viral disease , hepatitis c , virology , chronic infection , flaviviridae , serology , antibody , immune system
Chronic fatigue syndrome (CFS) is a debilitating heterogeneous disorder lacking consistent, objective physical or laboratory abnormalities. Among the hypothetical etiologies for CFS are chronic viral infections. The present controlled seroprevalence study found that, among typical CFS patients, evidence of hepatitis C virus (HCV) infection is uncommon. Only one of 36 patients and none of 14 controls were anti‐HCV positive. The positive patient had persistent aminotransferase elevations and prior posttransfusion hepatitis. Thus HCV infection is not a common feature of CFS and should not be routinely sought.