Premium
Effect of respiratory syncytial virus infection on mice with protein malnutrition
Author(s) -
PeñaCruz Victor,
Reiss Carol,
McIntosh Kenneth
Publication year - 1991
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890330402
Subject(s) - sendai virus , virus , virology , bronchiolitis , respiratory system , titer , paramyxoviridae , biology , pneumovirus , pneumonia , malnutrition , immunity , pneumovirinae , immunology , lung , medicine , viral disease , immune system , anatomy
Respiratory syncytial virus (RSV) pulmonary infection was produced in BALB/c mice fed protein‐deficient diets in an effort to understand the severity of viral pneumonia in infants in developing countries. As in previously published experiments with Sendai virus, animals on the deficient diet became clinically malnourished, and certain aspects of their cell‐mediated immunity were altered. The course of RSV infection in protein‐deprived mice was essentially identical to that in normally nourished animals. The titer of virus recovered from lung homogenates over time, as well as the histologic picture of bronchiolitis, were identical under all experimental conditions. This model, unlike that of Sendai virus infection, fails to demonstrate an effect of protein malnutrition on RSV infection.